This brief reviews and examines research and data from expansion and non-expansion states. This report first looks at the opportunities for Missouri concerning Medicaid expansion, including the impact on health insurance coverage, health outcomes, the state budget, and economic activity. The brief then reviews the challenges of Medicaid expansion, including enrollment, gaps in coverage, and possible budget shortfalls. Both sections cite to various studies on the issues. Both sections also consider Missouri’s current Medicaid program, known as MO HealthNet. The goal of this report is to gain a better understanding of the advantages and disadvantages of Medicaid expansion in Missouri.